Giant cell tumor (GCT) is the common benign tumor with high significant tendency for local recurrence. In the Philippines, GCT remains the most common benign bone tumor constituting more than half of all benign bone tumors and over one-fifth of all primary bone tumors.En bloc spondylectomy and related en bloc resection to remove the tumors in one piece with the aim of achieving complete excision and lowering risk of recurrence. Despite removal of tumors, there are reports of giant cell tumors recurrence after en bloc resection, the reported recurrence rate differ widely across the literature mainly due to variations in tumor location, surgical techniques, patient factors, length of follow-up, and definition of recurrence. Currently, there is limited to no consolidated estimate of recurrence of giant cell tumor following en bloc spondylectomy or en bloc resection across different anatomical sites. This study aims to present a case report describing the surgical technique performed for a patient with giant cell tumor of the spine who underwent en bloc spondylectomy. As a secondary objective, the study also aims to conduct a systematic review evaluating recurrence rates of GCT after en bloc spondylectomy and comparing recurrence outcomes across other treatment modalities, including surgical and non-surgical approaches such as denosumab therapy. A systematic review will be conducted using PubMed, MEDLINE, Scopus, Web of Science, and the Cochrane Library. Eligible studies will include original cohort studies and case series involving patients with GCT who underwent en bloc resection and reported recurrence outcomes. Extracted data will include study characteristics, tumor location, surgical approach, margin status, follow-up duration, and recurrence outcomes. A descriptive synthesis will be performed, while meta-analysis using a random-effects model will be considered if sufficient homogeneous data are available. The findings may contribute evidence to support surgical decision-making.